A conserved ancient domain joins the growing superfamily of 3′–5′ exonucleases
نویسنده
چکیده
analysis of the race-and-intelligence debate, and an absorbing tale of the bizarre cult that gathered around the novelist Ayn Rand, described by one of her followers as " the greatest human being who has ever lived. " Shermer's generalizations are less compelling. It scarcely needs a quotation from Sydney Hook (who he?) to instruct us that " Raphael's Sistine Madonna without Raphael, Beethoven's symphonies and sonatas without Beethoven, are inconceivable. In science, on the other hand, it is quite probable that most of the achievements of any given scientist would have been attained by other individuals working in the field. " Shermer is more laboured and less incisive than (among many others) Bertrand Russell in his numerous essays. Nor does he answer the question of the title. The Flat Earth Society still thrives, and I do not doubt that many people believe that garbage is collected twice a week by the leprechauns and that the moon is the repository of broken vows and unfulfilled desires (which, as we now know, is not the case). These propositions differ little from the conclusion (dressed up in the language of science) of Arthur Koestler and Sir Alastair Hardy, latterly Professor of Zoology at Oxford, that life's coincidences had supernatural origins. Dr Johnson said that wonders are willingly told and willingly heard, and so the majestic dictum of eighteenth century philosopher David Hume, which Shermer quotes with approval — that " no testimony is sufficient to establish a miracle unless the testimony be of such a kind, that its falsehood would be more miraculous than the fact which it endeavours to establish " — is disregarded. The improbable is just more interesting, and there's an end of it. has voiced a concern that many of us in academia share. In my experience, a medical textbook might be five years out of date, but middle and high school textbooks are often 25 years out of date. To make matters worse, the 'teaching life' of a medical textbook is only a couple of years, until the latest edition of a competing book comes out. In middle and high schools, however, this teaching life extends well beyond a decade in reasonably well funded districts — even more in poorer ones. As a parent, it is frustrating to have to watch my children learn absurdity upon falshood, and not to be able to correct the errors because they …
منابع مشابه
Editing of misaligned 3′-termini by an intrinsic 3′–5′ exonuclease activity residing in the PHP domain of a family X DNA polymerase
Bacillus subtilis gene yshC encodes a family X DNA polymerase (PolX(Bs)), whose biochemical features suggest that it plays a role during DNA repair processes. Here, we show that, in addition to the polymerization activity, PolX(Bs) possesses an intrinsic 3'-5' exonuclease activity specialized in resecting unannealed 3'-termini in a gapped DNA substrate. Biochemical analysis of a PolX(Bs) deleti...
متن کاملA Novel Single-Strand Specific 3′–5′ Exonuclease Found in the Hyperthermophilic Archaeon, Pyrococcus furiosus
Nucleases play important roles in all DNA transactions, including replication, repair, and recombination. Many different nucleases from bacterial and eukaryotic organisms have been identified and functionally characterized. However, our knowledge about the nucleases from Archaea, the third domain of life, is still limited. We searched for 3'-5' exonuclease activity in the hyperthermophilic arch...
متن کاملCloning of conserved regions of nontypeable Haemophilus influenzae hmw1 core binding domain
Colonization of nontypeable Haemophilus influenzae (NTHi) in nasopharynx causes respiratory tract disease. In 80% of clinical isolates, HMW proteins are the major adhesions and induce protective antibodies in the hosts. Therefore, it can be used as a vaccine candidate. The aim of this study is designing and cloning of the conserved regions of NTHi hmw1 core binding domain.In this study, the sta...
متن کاملEffect of drought stress on MYB gene expression and osmotic regulator levels of five durum wheat genotypes (Triticum turgidum L.)
Plant growth is greatly influenced by environmental stresses including water deficit, salinity and extreme temperatures. Therefore, the identification of genes, especially regulatory ones whose expression enables plants to adapt to or to tolerate these abiotic stresses, is very essential. MYB proteins, a superfamily of transcription factors, play regulatory roles in developmental processes and ...
متن کاملRrp17p Is a Eukaryotic Exonuclease Required for 5′ End Processing of Pre-60S Ribosomal RNA
Ribosomal processing requires a series of endo- and exonucleolytic steps for the production of mature ribosomes, of which most have been described. To ensure ribosome synthesis, 3' end formation of rRNA uses multiple nucleases acting in parallel; however, a similar parallel mechanism had not been described for 5' end maturation. Here, we identify Rrp17p as a previously unidentified 5'-3' exonuc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 7 شماره
صفحات -
تاریخ انتشار 1997